I find the best way to play with such a large group is to play games where the group is split into teams. The teams can be split however you want although it is nice to try and make them even in their skills so everyone has a fair chance of winning.
Some great team games include:
Cranium - a mix of trivia, charades, pictionary and just plain fun - I've never met anyone that doesn't LOVE this game
Taboo - you need to make your team say a word but you have a list of 5 words you cannot say - it can get really silly and is not as easy as it sounds
Rummoli - a card game that is super easy to learn but lots of fun to play and rummoli board are cheap and easy to find
Outburst - your team is given a category and you need to try and guess items from that category - the other team is checking off your responses from a given list, the more you get from the list the more points - this game is great because there are often really silly answers on the category lists
Scattegories - although normally not played in teams it can be, especially when in a large group - you need to think of creative answers that all start with the same letter
Good luck with your next get together. I hope you have lots of fun!